Upstream Bio Inc. Major Shareholders & Ownership History
| Major Shareholder Name | Reporting Date | Shares Held | Market Value | Change in Shares | Ownership |
|---|---|---|---|---|---|
| FMR LLC | 08/13/2026 | 8.16 M | $56.49 M | 0.76% | 14.96% |
| ORBIMED ADVISORS LLC | 08/14/2026 | 5.69 M | $39.40 M | 0.00% | 10.43% |
| NORGES BANK | 08/12/2026 | 3.77 M | $26.08 M | 100.00% | 6.91% |
| BLACKROCK, INC. | 08/07/2026 | 3.75 M | $25.97 M | 11.35% | 6.88% |
| DECHENG CAPITAL LLC | 08/14/2026 | 2.72 M | $18.86 M | 0.00% | 4.99% |
| ENAVATE SCIENCES GP, LLC | 08/14/2026 | 2.46 M | $17.02 M | 0.00% | 4.51% |
| VANGUARD CAPITAL MANAGEMENT LLC | 08/13/2026 | 1.88 M | $12.99 M | 0.17% | 3.44% |
| MILLENNIUM MANAGEMENT LLC | 08/14/2026 | 1.14 M | $7.91 M | 22.03% | 2.10% |
| D. E. SHAW & CO., INC. | 08/14/2026 | 1.04 M | $7.17 M | 26.27% | 1.90% |
| JPMORGAN CHASE & CO | 08/12/2026 | 1.01 M | $7.01 M | 118.58% | 1.85% |
| QUBE RESEARCH & TECHNOLOGIES LTD | 08/14/2026 | 978.50 K | $6.77 M | 58.00% | 1.79% |
| PARKMAN HEALTHCARE PARTNERS LLC | 08/14/2026 | 935.25 K | $6.47 M | 18.87% | 1.71% |
| GEODE CAPITAL MANAGEMENT, LLC | 08/12/2026 | 931.26 K | $6.45 M | -2.04% | 1.71% |
| SEB ASSET MANAGEMENT AB | 08/04/2026 | 878.47 K | $6.08 M | 0.00% | 1.61% |
| WOODLINE PARTNERS LP | 08/14/2026 | 831.48 K | $5.75 M | 0.00% | 1.52% |
| STATE STREET CORP | 09/22/2026 | 766.32 K | $5.30 M | 8.64% | 1.40% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 08/13/2026 | 712.67 K | $4.93 M | -2.07% | 1.31% |
| Y-INTERCEPT (HONG KONG) LTD | 07/14/2026 | 693.56 K | $4.80 M | -30.69% | 1.27% |
| BAIN CAPITAL LIFE SCIENCES INVESTORS, LLC | 08/14/2026 | 600.95 K | $4.16 M | -30.70% | 1.10% |
| AQR CAPITAL MANAGEMENT LLC | 08/14/2026 | 544.87 K | $3.77 M | 654.97% | 1.00% |
| MORGAN STANLEY | 08/13/2026 | 524.63 K | $3.63 M | -5.06% | 0.96% |
| BNP PARIBAS FINANCIAL MARKETS | 08/13/2026 | 511.55 K | $3.54 M | 305.99% | 0.94% |
| WALLEYE CAPITAL LLC | 08/03/2026 | 498.49 K | $3.45 M | 100.00% | 0.91% |
| TREXQUANT INVESTMENT LP | 08/14/2026 | 466.43 K | $3.23 M | 164.03% | 0.85% |
| POINT72 ASSET MANAGEMENT, L.P. | 08/14/2026 | 453.01 K | $3.13 M | 154.26% | 0.83% |
| BANK OF AMERICA CORP /DE/ | 08/14/2026 | 391.76 K | $2.71 M | 708.42% | 0.72% |
| DIMENSIONAL FUND ADVISORS LP | 08/11/2026 | 381.61 K | $2.64 M | 377.00% | 0.70% |
| ALTSHULER SHAHAM LTD | 08/12/2026 | 380.06 K | $2.63 M | 0.00% | 0.70% |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 08/13/2026 | 357.76 K | $2.48 M | 93.29% | 0.66% |
| SAMSARA BIOCAPITAL, LLC | 08/14/2026 | 353.72 K | $2.45 M | -51.94% | 0.65% |
| PROPEL BIO MANAGEMENT, LLC | 08/13/2026 | 350.39 K | $2.42 M | 2.52% | 0.64% |
| WELLINGTON MANAGEMENT GROUP LLP | 08/14/2026 | 342.35 K | $2.37 M | 0.00% | 0.63% |
| NORTHERN TRUST CORP | 08/13/2026 | 297.35 K | $2.06 M | 13.93% | 0.54% |
| SQUAREPOINT OPS LLC | 08/14/2026 | 290.90 K | $2.01 M | 551.87% | 0.53% |
| VOLEON CAPITAL MANAGEMENT LP | 08/14/2026 | 285.23 K | $1.97 M | 100.00% | 0.52% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 08/14/2026 | 262.46 K | $1.82 M | 1.83% | 0.48% |
| SIXTH STREET PARTNERS MANAGEMENT COMPANY, L.P. | 08/14/2026 | 262.46 K | $1.82 M | 100.00% | 0.48% |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 08/14/2026 | 253.09 K | $1.75 M | 100.00% | 0.46% |
| GOLDMAN SACHS GROUP INC | 08/14/2026 | 246.92 K | $1.71 M | -22.01% | 0.45% |
| XTX TOPCO LTD | 08/14/2026 | 242.35 K | $1.68 M | 15.80% | 0.44% |
| DEUTSCHE BANK AG\ | 08/07/2026 | 241.45 K | $1.67 M | 33.48% | 0.44% |
| VANGUARD FIDUCIARY TRUST CO | 08/13/2026 | 239.62 K | $1.66 M | 6.90% | 0.44% |
| UBS GROUP AG | 08/13/2026 | 234.71 K | $1.62 M | 1.50% | 0.43% |
| SCHONFELD STRATEGIC ADVISORS LLC | 08/14/2026 | 225.76 K | $1.56 M | 39.92% | 0.41% |
| JUMP FINANCIAL, LLC | 08/13/2026 | 223.22 K | $1.54 M | -30.11% | 0.41% |
| SPHERA FUNDS MANAGEMENT LTD. | 08/14/2026 | 219.70 K | $1.52 M | -38.63% | 0.40% |
| ACADIAN ASSET MANAGEMENT LLC | 08/13/2026 | 175.11 K | $1.21 M | 100.00% | 0.32% |
| HRT FINANCIAL LP | 08/14/2026 | 170.59 K | $1.18 M | 100.00% | 0.31% |
| BOXER CAPITAL MANAGEMENT, LLC | 08/14/2026 | 150.00 K | $1.04 M | 0.00% | 0.27% |
| RENAISSANCE TECHNOLOGIES LLC | 08/13/2026 | 131.30 K | $908.60 K | 111.43% | 0.24% |
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Upstream Bio Inc. institutional Ownership - FAQ's
During the previous two years, 176 institutional investors and hedge funds held shares of Upstream Bio Inc.. The most heavily invested institutionals were:
SEB Asset Management AB: 878,473
DIMENSIONAL FUND ADVISORS LP: 374,836
ALPS ADVISORS INC: 72,045
Simplify Asset Management Inc.: 62,113
Allspring Global Investments Holdings, LLC: 44,947
CITIGROUP INC: 35,733
93.17% of Upstream Bio Inc. stock is owned by institutional investors.
Institutional investors have bought a total of 53.00 M shares in the last 24 months. This purchase volume represents approximately $427.20 M in transactions.