Upstream Bio Inc. Major Shareholders & Ownership History
| Major Shareholder Name | Reporting Date | Shares Held | Market Value | Change in Shares | Ownership |
|---|---|---|---|---|---|
| FMR LLC | 05/15/2026 | 8.10 M | $72.91 M | 7.76% | 14.94% |
| ORBIMED ADVISORS LLC | 05/15/2026 | 5.69 M | $51.24 M | 0.00% | 10.50% |
| BLACKROCK, INC. | 05/13/2026 | 3.37 M | $30.34 M | 0.78% | 6.21% |
| DECHENG CAPITAL LLC | 05/13/2026 | 2.72 M | $24.52 M | -13.31% | 5.02% |
| ENAVATE SCIENCES GP, LLC | 05/15/2026 | 2.46 M | $22.14 M | 0.00% | 4.54% |
| 05/15/2026 | 1.87 M | $16.86 M | 100.00% | 3.45% | |
| Y-INTERCEPT (HONG KONG) LTD | 04/27/2026 | 1.00 M | $9.01 M | 2,049.17% | 1.84% |
| FEDERATED HERMES, INC. | 05/11/2026 | 979.76 K | $8.82 M | 203,169.29% | 1.81% |
| GEODE CAPITAL MANAGEMENT, LLC | 05/15/2026 | 950.62 K | $8.56 M | 11.59% | 1.75% |
| MILLENNIUM MANAGEMENT LLC | 05/15/2026 | 937.32 K | $8.44 M | 81.21% | 1.73% |
| 05/07/2026 | 878.47 K | $7.91 M | 100.00% | 1.62% | |
| BAIN CAPITAL LIFE SCIENCES INVESTORS, LLC | 05/15/2026 | 867.21 K | $7.80 M | -34.77% | 1.60% |
| WOODLINE PARTNERS LP | 05/15/2026 | 831.48 K | $7.48 M | 9.37% | 1.53% |
| D. E. SHAW & CO., INC. | 05/15/2026 | 820.48 K | $7.38 M | 2,928.61% | 1.51% |
| PARKMAN HEALTHCARE PARTNERS LLC | 05/15/2026 | 786.78 K | $7.08 M | -5.72% | 1.45% |
| SAMSARA BIOCAPITAL, LLC | 05/15/2026 | 736.05 K | $6.62 M | 0.00% | 1.36% |
| PICTET ASSET MANAGEMENT HOLDING SA | 04/22/2026 | 733.43 K | $6.60 M | -5.14% | 1.35% |
| 05/08/2026 | 727.71 K | $6.55 M | 100.00% | 1.34% | |
| STATE STREET CORP | 05/15/2026 | 705.35 K | $6.35 M | -46.53% | 1.30% |
| HSBC HOLDINGS PLC | 04/30/2026 | 640.33 K | $5.76 M | 100.00% | 1.18% |
| QUBE RESEARCH & TECHNOLOGIES LTD | 05/15/2026 | 619.32 K | $5.57 M | 100.00% | 1.14% |
| MORGAN STANLEY | 05/15/2026 | 552.61 K | $4.97 M | 352.71% | 1.02% |
| JPMORGAN CHASE & CO | 05/13/2026 | 463.00 K | $4.07 M | 319.84% | 0.85% |
| NANTAHALA CAPITAL MANAGEMENT, LLC | 05/15/2026 | 400.00 K | $3.60 M | -19.19% | 0.74% |
| ALTSHULER SHAHAM LTD | 05/18/2026 | 380.06 K | $3.42 M | -71.67% | 0.70% |
| SPHERA FUNDS MANAGEMENT LTD. | 05/15/2026 | 358.00 K | $3.22 M | 100.00% | 0.66% |
| WELLINGTON MANAGEMENT GROUP LLP | 05/15/2026 | 342.35 K | $3.08 M | -61.74% | 0.63% |
| PROPEL BIO MANAGEMENT, LLC | 05/14/2026 | 341.78 K | $3.10 M | 100.00% | 0.63% |
| JUMP FINANCIAL, LLC | 05/14/2026 | 319.40 K | $2.87 M | 100.00% | 0.59% |
| GOLDMAN SACHS GROUP INC | 05/15/2026 | 316.59 K | $2.85 M | -5.07% | 0.58% |
| ALYESKA INVESTMENT GROUP, L.P. | 05/15/2026 | 298.33 K | $2.68 M | 0.00% | 0.55% |
| NORTHERN TRUST CORP | 05/14/2026 | 260.99 K | $2.35 M | 10.22% | 0.48% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 05/15/2026 | 257.73 K | $2.32 M | -9.55% | 0.48% |
| PROSIGHT MANAGEMENT, LP | 05/15/2026 | 241.12 K | $2.17 M | 100.00% | 0.44% |
| UBS GROUP AG | 05/05/2026 | 231.25 K | $2.08 M | -87.20% | 0.43% |
| VANGUARD FIDUCIARY TRUST CO | 05/08/2026 | 224.16 K | $2.02 M | 100.00% | 0.41% |
| XTX TOPCO LTD | 05/15/2026 | 209.28 K | $1.88 M | 1,286.77% | 0.39% |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 05/14/2026 | 185.09 K | $1.67 M | 100.00% | 0.34% |
| TCG CROSSOVER MANAGEMENT, LLC | 05/15/2026 | 181.06 K | $1.63 M | -75.66% | 0.33% |
| DEUTSCHE BANK AG\ | 05/06/2026 | 180.89 K | $1.63 M | 41.52% | 0.33% |
| POINT72 ASSET MANAGEMENT, L.P. | 05/15/2026 | 178.17 K | $1.60 M | 100.00% | 0.33% |
| TREXQUANT INVESTMENT LP | 05/15/2026 | 176.66 K | $1.59 M | 468.96% | 0.33% |
| SCHONFELD STRATEGIC ADVISORS LLC | 05/15/2026 | 161.35 K | $1.45 M | 39.33% | 0.30% |
| BOXER CAPITAL MANAGEMENT, LLC | 05/15/2026 | 150.00 K | $1.35 M | 0.00% | 0.28% |
| BNP PARIBAS ARBITRAGE, SNC | 05/12/2026 | 126.00 K | $1.13 M | 2,432.15% | 0.23% |
| EXODUSPOINT CAPITAL MANAGEMENT, LP | 05/14/2026 | 91.43 K | $822.88 K | 21.26% | 0.17% |
| AMERICAN CENTURY COMPANIES INC | 05/15/2026 | 87.62 K | $788.62 K | -0.15% | 0.16% |
| BANK OF NEW YORK MELLON CORP | 05/05/2026 | 81.38 K | $732.45 K | -4.09% | 0.15% |
| DIMENSIONAL FUND ADVISORS LP | 05/07/2026 | 80.00 K | $719.49 K | 100.00% | 0.15% |
| SIMPLIFY ASSET MANAGEMENT INC. | 04/27/2026 | 77.79 K | $700.14 K | 100.00% | 0.14% |
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Upstream Bio Inc. institutional Ownership - FAQ's
During the previous two years, 172 institutional investors and hedge funds held shares of Upstream Bio Inc.. The most heavily invested institutionals were:
FMR LLC: 8.1 M
ORBIMED ADVISORS LLC: 5.69 M
BlackRock, Inc.: 3.37 M
Decheng Capital LLC: 2.72 M
Enavate Sciences GP, LLC: 2.46 M
Y-Intercept (Hong Kong) Ltd: 1 M
82.76% of Upstream Bio Inc. stock is owned by institutional investors.
Institutional investors have bought a total of 46.70 M shares in the last 24 months. This purchase volume represents approximately $376.38 M in transactions.