Spyre Therapeutics Inc. Major Shareholders & Ownership History
| Major Shareholder Name | Reporting Date | Shares Held | Market Value | Change in Shares | Ownership |
|---|---|---|---|---|---|
| FMR LLC | 08/13/2026 | 13.03 M | $1.16 B | 10.57% | 15.37% |
| BLACKROCK, INC. | 08/07/2026 | 6.51 M | $577.66 M | 17.85% | 7.68% |
| PERCEPTIVE ADVISORS LLC | 08/14/2026 | 4.32 M | $383.48 M | 14.18% | 5.10% |
| RTW INVESTMENTS, LP | 08/14/2026 | 4.25 M | $377.49 M | 1.92% | 5.02% |
| PARADIGM BIOCAPITAL ADVISORS LP | 08/14/2026 | 3.84 M | $340.98 M | 96.23% | 4.53% |
| VANGUARD CAPITAL MANAGEMENT LLC | 08/13/2026 | 3.45 M | $306.17 M | 12.80% | 4.07% |
| STATE STREET CORP | 08/07/2026 | 3.06 M | $271.44 M | 17.28% | 3.61% |
| VR ADVISER, LLC | 08/14/2026 | 2.99 M | $265.05 M | -18.99% | 3.52% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 08/14/2026 | 2.96 M | $262.87 M | 85.20% | 3.49% |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 08/14/2026 | 2.80 M | $248.51 M | 0.30% | 3.30% |
| GEODE CAPITAL MANAGEMENT, LLC | 08/12/2026 | 2.56 M | $239.26 M | 48.89% | 3.02% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 08/13/2026 | 2.33 M | $206.87 M | 298.22% | 2.75% |
| CAPITAL WORLD INVESTORS | 08/12/2026 | 2.32 M | $205.57 M | 247.39% | 2.73% |
| JUPITER TOPCO LLC | 08/14/2026 | 2.21 M | $195.88 M | 100.00% | 2.60% |
| TCG CROSSOVER MANAGEMENT, LLC | 08/14/2026 | 1.90 M | $168.73 M | 0.00% | 2.24% |
| TANG CAPITAL MANAGEMENT LLC | 08/14/2026 | 1.89 M | $167.99 M | 0.00% | 2.23% |
| BANK OF AMERICA CORP /DE/ | 08/14/2026 | 1.78 M | $157.84 M | 44.77% | 2.10% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 08/14/2026 | 1.72 M | $152.91 M | 100.00% | 2.03% |
| WELLINGTON MANAGEMENT GROUP LLP | 08/14/2026 | 1.58 M | $140.41 M | -13.33% | 1.87% |
| GOLDMAN SACHS GROUP INC | 08/14/2026 | 1.48 M | $131.22 M | 447.56% | 1.74% |
| FRANKLIN RESOURCES INC | 08/13/2026 | 1.47 M | $130.77 M | 66.84% | 1.74% |
| REMEDIUM CAPITAL PARTNERS, LLC | 08/07/2026 | 1.46 M | $129.99 M | 0.55% | 1.73% |
| AFFINITY ASSET ADVISORS, LLC | 08/13/2026 | 1.28 M | $113.56 M | 0.00% | 1.51% |
| JPMORGAN CHASE & CO | 08/12/2026 | 1.09 M | $98.87 M | 11.61% | 1.29% |
| HOLOCENE ADVISORS, LP | 08/14/2026 | 1.02 M | $90.13 M | 100.00% | 1.20% |
| MARSHALL WACE, LLP | 08/13/2026 | 991.69 K | $88.04 M | 612.12% | 1.17% |
| POLAR CAPITAL HOLDINGS PLC | 08/14/2026 | 988.01 K | $87.72 M | 24.62% | 1.17% |
| SIREN, L.L.C. | 08/13/2026 | 968.60 K | $85.99 M | 18.32% | 1.14% |
| CAPITAL INTERNATIONAL INVESTORS | 08/12/2026 | 955.20 K | $84.80 M | -45.30% | 1.13% |
| BRAIDWELL LP | 08/14/2026 | 879.47 K | $78.08 M | -5.72% | 1.04% |
| COMMODORE CAPITAL LP | 08/14/2026 | 846.79 K | $75.18 M | -55.72% | 1.00% |
| UBS GROUP AG | 08/13/2026 | 843.07 K | $74.85 M | 25.60% | 1.00% |
| NORTHERN TRUST CORP | 08/13/2026 | 674.53 K | $59.88 M | 16.52% | 0.80% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 08/14/2026 | 652.96 K | $57.97 M | 16.05% | 0.77% |
| SIXTH STREET PARTNERS MANAGEMENT COMPANY, L.P. | 08/14/2026 | 652.96 K | $57.97 M | 100.00% | 0.77% |
| PICTET ASSET MANAGEMENT HOLDING SA | 07/30/2026 | 628.14 K | $55.77 M | 27.76% | 0.74% |
| EMERALD ADVISERS, LLC | 08/05/2026 | 567.43 K | $50.38 M | -7.49% | 0.67% |
| VICTORY CAPITAL MANAGEMENT INC | 08/07/2026 | 553.98 K | $49.18 M | 89.64% | 0.65% |
| VANGUARD FIDUCIARY TRUST CO | 08/13/2026 | 551.39 K | $48.95 M | 18.67% | 0.65% |
| CANDRIAM S.C.A. | 08/13/2026 | 546.31 K | $48.45 M | -10.48% | 0.64% |
| UBS ASSET MANAGEMENT AMERICAS INC | 08/13/2026 | 522.07 K | $46.35 M | 151.83% | 0.62% |
| MORGAN STANLEY | 08/13/2026 | 499.96 K | $44.39 M | 102.64% | 0.59% |
| VOYA INVESTMENT MANAGEMENT LLC | 08/12/2026 | 431.69 K | $38.33 M | 699.88% | 0.51% |
| EMERALD MUTUAL FUND ADVISERS TRUST | 08/05/2026 | 401.27 K | $35.62 M | -1.68% | 0.47% |
| SAMLYN CAPITAL, LLC | 08/14/2026 | 400.08 K | $35.52 M | 0.86% | 0.47% |
| AMERIPRISE FINANCIAL INC | 08/14/2026 | 356.08 K | $31.61 M | 123.65% | 0.42% |
| INTEGRAL HEALTH ASSET MANAGEMENT, LLC | 08/14/2026 | 325.00 K | $28.85 M | 100.00% | 0.38% |
| WOODLINE PARTNERS LP | 08/14/2026 | 306.05 K | $27.17 M | 15.10% | 0.36% |
| JENNISON ASSOCIATES LLC | 08/03/2026 | 303.18 K | $26.92 M | 100.00% | 0.36% |
| ADAR1 CAPITAL MANAGEMENT, LLC | 08/14/2026 | 283.98 K | $25.21 M | -16.06% | 0.34% |
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Spyre Therapeutics Inc. institutional Ownership - FAQ's
During the previous two years, 301 institutional investors and hedge funds held shares of Spyre Therapeutics Inc.. The most heavily invested institutionals were:
FMR LLC: 13.03 M
BlackRock, Inc.: 6.51 M
PERCEPTIVE ADVISORS LLC: 4.32 M
RTW INVESTMENTS, LP: 4.25 M
Paradigm Biocapital Advisors LP: 3.84 M
VANGUARD CAPITAL MANAGEMENT LLC: 3.45 M
113.87% of Spyre Therapeutics Inc. stock is owned by institutional investors.
Institutional investors have bought a total of 105.51 M shares in the last 24 months. This purchase volume represents approximately $4.33 B in transactions.