Spyre Therapeutics, Inc. Major Shareholders & Ownership History
| Major Shareholder Name | Reporting Date | Shares Held | Market Value | Change in Shares | Ownership |
|---|---|---|---|---|---|
| FMR LLC | 11/13/2025 | 9.06 M | $151.85 M | 0.08% | 12.09% |
| FAIRMOUNT FUNDS MANAGEMENT LLC | 11/14/2025 | 4.02 M | $67.34 M | 0.00% | 5.36% |
| BLACKROCK, INC. | 11/12/2025 | 3.98 M | $66.75 M | -0.61% | 5.32% |
| RTW INVESTMENTS, LP | 11/14/2025 | 3.62 M | $60.70 M | 0.00% | 4.83% |
| TANG CAPITAL MANAGEMENT LLC | 11/14/2025 | 3.20 M | $53.63 M | 0.00% | 4.27% |
| VANGUARD GROUP INC | 11/07/2025 | 3.05 M | $51.13 M | -0.52% | 4.07% |
| VR ADVISER, LLC | 11/14/2025 | 2.69 M | $45.01 M | 0.00% | 3.58% |
| BRAIDWELL LP | 11/14/2025 | 2.58 M | $43.21 M | 0.00% | 3.44% |
| CAPITAL INTERNATIONAL INVESTORS | 11/13/2025 | 2.39 M | $40.10 M | 0.00% | 3.19% |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 11/14/2025 | 2.06 M | $34.53 M | -1.21% | 2.75% |
| COMMODORE CAPITAL LP | 11/14/2025 | 1.99 M | $33.32 M | 0.00% | 2.65% |
| STATE STREET CORP | 11/14/2025 | 1.79 M | $29.92 M | 11.90% | 2.38% |
| WELLINGTON MANAGEMENT GROUP LLP | 11/14/2025 | 1.64 M | $27.49 M | 8.38% | 2.19% |
| PARADIGM BIOCAPITAL ADVISORS LP | 11/14/2025 | 1.47 M | $24.59 M | -21.56% | 1.96% |
| AFFINITY ASSET ADVISORS, LLC | 11/13/2025 | 1.42 M | $23.79 M | 133.95% | 1.89% |
| JEFFERIES FINANCIAL GROUP INC. | 11/13/2025 | 1.39 M | $23.28 M | 0.00% | 1.85% |
| PERCEPTIVE ADVISORS LLC | 11/14/2025 | 1.23 M | $20.61 M | -19.62% | 1.64% |
| GEODE CAPITAL MANAGEMENT, LLC | 11/12/2025 | 1.23 M | $20.54 M | -0.17% | 1.64% |
| TCG CROSSOVER MANAGEMENT, LLC | 11/17/2025 | 1.10 M | $18.45 M | 100.00% | 1.47% |
| PICTET ASSET MANAGEMENT HOLDING SA | 11/18/2025 | 1.04 M | $17.37 M | -4.00% | 1.38% |
| BAKER BROS. ADVISORS LP | 11/14/2025 | 1.00 M | $16.76 M | 59.57% | 1.33% |
| FRANKLIN RESOURCES INC | 11/13/2025 | 795.28 K | $13.33 M | 0.00% | 1.06% |
| POLAR CAPITAL HOLDINGS PLC | 11/14/2025 | 788.79 K | $13.22 M | 5.88% | 1.05% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 11/14/2025 | 620.62 K | $10.40 M | -33.30% | 0.83% |
| DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C) | 11/14/2025 | 613.67 K | $10.29 M | 0.00% | 0.82% |
| EMERALD ADVISERS, LLC | 10/30/2025 | 548.71 K | $9.20 M | -3.03% | 0.73% |
| BLACKSTONE INC. | 11/14/2025 | 501.00 K | $8.40 M | 2.40% | 0.67% |
| NORTHERN TRUST CORP | 11/14/2025 | 442.04 K | $7.41 M | 1.16% | 0.59% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 11/10/2025 | 425.35 K | $7.13 M | 1.63% | 0.57% |
| MILLENNIUM MANAGEMENT LLC | 11/14/2025 | 408.20 K | $6.84 M | 100.00% | 0.54% |
| CANDRIAM S.C.A. | 11/06/2025 | 404.36 K | $6.78 M | 64.35% | 0.54% |
| UBS GROUP AG | 11/13/2025 | 385.59 K | $6.46 M | -16.69% | 0.51% |
| SIREN, L.L.C. | 11/13/2025 | 368.60 K | $6.18 M | 0.00% | 0.49% |
| BANK OF AMERICA CORP /DE/ | 11/14/2025 | 344.80 K | $5.78 M | -13.01% | 0.46% |
| JPMORGAN CHASE & CO | 11/26/2025 | 275.98 K | $4.63 M | 483.73% | 0.45% |
| MORGAN STANLEY | 11/14/2025 | 334.72 K | $5.61 M | -50.12% | 0.45% |
| GOLDMAN SACHS GROUP INC | 11/14/2025 | 329.53 K | $5.52 M | -37.04% | 0.44% |
| VICTORY CAPITAL MANAGEMENT INC | 11/12/2025 | 326.08 K | $5.47 M | -7.92% | 0.44% |
| BNP PARIBAS ARBITRAGE, SNC | 11/13/2025 | 315.91 K | $5.29 M | 41.46% | 0.42% |
| EMERALD MUTUAL FUND ADVISERS TRUST | 10/30/2025 | 308.21 K | $5.17 M | -6.44% | 0.41% |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 11/14/2025 | 264.32 K | $4.43 M | -5.24% | 0.35% |
| HIGHVISTA STRATEGIES LLC | 11/14/2025 | 215.75 K | $3.62 M | 91.26% | 0.29% |
| PARKMAN HEALTHCARE PARTNERS LLC | 11/14/2025 | 200.75 K | $3.36 M | 100.00% | 0.27% |
| CAPITAL WORLD INVESTORS | 11/13/2025 | 200.17 K | $3.35 M | -42.93% | 0.27% |
| BARCLAYS PLC | 11/12/2025 | 168.33 K | $2.82 M | -22.30% | 0.22% |
| ARMISTICE CAPITAL, LLC | 11/17/2025 | 156.00 K | $2.61 M | -9.30% | 0.21% |
| BANK OF NEW YORK MELLON CORP | 11/03/2025 | 135.96 K | $2.28 M | 2.88% | 0.18% |
| WOODLINE PARTNERS LP | 11/14/2025 | 131.88 K | $2.21 M | -71.65% | 0.18% |
| UNIVERSAL- BETEILIGUNGS- UND SERVICEGESELLSCHAFT MBH | 10/30/2025 | 110.46 K | $1.85 M | 1.07% | 0.15% |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 11/13/2025 | 107.74 K | $1.76 M | -16.84% | 0.14% |
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Spyre Therapeutics, Inc. institutional Ownership - FAQ's
During the previous two years, 157 institutional investors and hedge funds held shares of Spyre Therapeutics, Inc.. The most heavily invested institutionals were:
FMR LLC: 9.06 M
Fairmount Funds Management LLC: 4.02 M
BlackRock, Inc.: 3.98 M
RTW INVESTMENTS, LP: 3.62 M
TANG CAPITAL MANAGEMENT LLC: 3.2 M
VANGUARD GROUP INC: 3.05 M
85.82% of Spyre Therapeutics, Inc. stock is owned by institutional investors.
Institutional investors have bought a total of 67.63 M shares in the last 24 months. This purchase volume represents approximately $1.07 B in transactions.