Spyre Therapeutics Inc. Major Shareholders & Ownership History
| Major Shareholder Name | Reporting Date | Shares Held | Market Value | Change in Shares | Ownership |
|---|---|---|---|---|---|
| FMR LLC | 05/15/2026 | 11.78 M | $594.23 M | 1.22% | 3.40% |
| BLACKROCK, INC. | 05/13/2026 | 5.52 M | $278.49 M | -0.02% | 1.60% |
| RTW INVESTMENTS, LP | 05/15/2026 | 4.17 M | $210.44 M | 0.00% | 1.21% |
| FAIRMOUNT FUNDS MANAGEMENT LLC | 05/15/2026 | 4.02 M | $202.67 M | 0.00% | 1.16% |
| PERCEPTIVE ADVISORS LLC | 05/29/2026 | 3.78 M | $190.83 M | 23.26% | 1.09% |
| VR ADVISER, LLC | 05/15/2026 | 3.69 M | $185.89 M | 0.00% | 1.07% |
| 05/15/2026 | 3.06 M | $154.22 M | 100.00% | 0.88% | |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 05/15/2026 | 2.79 M | $140.77 M | -3.18% | 0.81% |
| STATE STREET CORP | 05/15/2026 | 2.61 M | $131.50 M | 15.21% | 0.75% |
| PARADIGM BIOCAPITAL ADVISORS LP | 05/15/2026 | 1.96 M | $98.72 M | 33.40% | 0.57% |
| COMMODORE CAPITAL LP | 05/15/2026 | 1.91 M | $96.46 M | -19.93% | 0.55% |
| TCG CROSSOVER MANAGEMENT, LLC | 05/15/2026 | 1.90 M | $95.87 M | 0.00% | 0.55% |
| TANG CAPITAL MANAGEMENT LLC | 05/15/2026 | 1.89 M | $95.44 M | 0.00% | 0.55% |
| WELLINGTON MANAGEMENT GROUP LLP | 05/15/2026 | 1.82 M | $92.04 M | 17.78% | 0.53% |
| CAPITAL INTERNATIONAL INVESTORS | 05/13/2026 | 1.75 M | $88.07 M | -50.00% | 0.50% |
| GEODE CAPITAL MANAGEMENT, LLC | 05/15/2026 | 1.72 M | $86.82 M | 3.72% | 0.50% |
| JANUS HENDERSON GROUP PLC | 05/18/2026 | 1.66 M | $83.59 M | -9.45% | 0.48% |
| RA CAPITAL MANAGEMENT, L.P. | 05/15/2026 | 1.62 M | $81.79 M | 0.00% | 0.47% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 05/15/2026 | 1.60 M | $80.64 M | -0.20% | 0.46% |
| 05/19/2026 | 1.46 M | $73.45 M | 0.00% | 0.42% | |
| AFFINITY ASSET ADVISORS, LLC | 05/14/2026 | 1.28 M | $64.52 M | -10.71% | 0.37% |
| BANK OF AMERICA CORP /DE/ | 05/18/2026 | 1.23 M | $61.95 M | 192.59% | 0.35% |
| BAKER BROS. ADVISORS LP | 05/15/2026 | 1.00 M | $50.44 M | 0.00% | 0.29% |
| JPMORGAN CHASE & CO | 05/13/2026 | 979.30 K | $44.48 M | 1,455.65% | 0.28% |
| BRAIDWELL LP | 05/15/2026 | 932.82 K | $47.05 M | -42.93% | 0.27% |
| FRANKLIN RESOURCES INC | 05/13/2026 | 882.83 K | $44.53 M | -20.41% | 0.26% |
| CALIGAN PARTNERS LP | 05/15/2026 | 878.13 K | $44.29 M | 100.00% | 0.25% |
| SIREN, L.L.C. | 05/14/2026 | 818.60 K | $41.29 M | 0.00% | 0.24% |
| POLAR CAPITAL HOLDINGS PLC | 05/15/2026 | 792.85 K | $39.99 M | 7.09% | 0.23% |
| UBS GROUP AG | 05/05/2026 | 671.24 K | $33.86 M | -1.37% | 0.19% |
| CAPITAL WORLD INVESTORS | 05/13/2026 | 666.56 K | $33.62 M | 233.00% | 0.19% |
| EMERALD ADVISERS, LLC | 05/04/2026 | 613.37 K | $30.94 M | -3.58% | 0.18% |
| CANDRIAM S.C.A. | 04/30/2026 | 610.28 K | $30.78 M | 43.42% | 0.18% |
| 05/08/2026 | 585.13 K | $29.51 M | 100.00% | 0.17% | |
| NORTHERN TRUST CORP | 05/14/2026 | 578.91 K | $29.20 M | 3.19% | 0.17% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 05/15/2026 | 562.65 K | $28.38 M | -2.08% | 0.16% |
| PICTET ASSET MANAGEMENT HOLDING SA | 04/22/2026 | 491.65 K | $24.80 M | -46.21% | 0.14% |
| VANGUARD FIDUCIARY TRUST CO | 05/08/2026 | 464.65 K | $23.44 M | 100.00% | 0.13% |
| EMERALD MUTUAL FUND ADVISERS TRUST | 05/04/2026 | 408.11 K | $20.59 M | -1.03% | 0.12% |
| SAMLYN CAPITAL, LLC | 05/15/2026 | 396.66 K | $20.01 M | 100.00% | 0.11% |
| ADAR1 CAPITAL MANAGEMENT, LLC | 05/18/2026 | 338.32 K | $17.07 M | 893.58% | 0.10% |
| BLACKSTONE INC. | 05/15/2026 | 292.85 K | $14.77 M | -41.55% | 0.08% |
| VICTORY CAPITAL MANAGEMENT INC | 05/15/2026 | 292.13 K | $14.73 M | 99.98% | 0.08% |
| GOLDMAN SACHS GROUP INC | 05/15/2026 | 269.94 K | $13.62 M | -1.86% | 0.08% |
| WOODLINE PARTNERS LP | 05/15/2026 | 265.89 K | $13.41 M | 0.00% | 0.08% |
| MORGAN STANLEY | 05/15/2026 | 246.72 K | $12.44 M | 35.02% | 0.07% |
| CAPTION MANAGEMENT, LLC | 05/15/2026 | 237.80 K | $11.99 M | -40.54% | 0.07% |
| UBS ASSET MANAGEMENT AMERICAS INC | 05/13/2026 | 207.31 K | $10.46 M | 233.22% | 0.06% |
| BOOTHBAY FUND MANAGEMENT, LLC | 05/15/2026 | 193.03 K | $9.74 M | 100.00% | 0.06% |
| BANK OF NEW YORK MELLON CORP | 05/05/2026 | 191.40 K | $9.65 M | -0.74% | 0.06% |
Explore Related Stocks for Market Trends
Explore our related stocks for the latest market trends and stock news to stay informed and make better decisions.
Spyre Therapeutics Inc. institutional Ownership - FAQ's
During the previous two years, 209 institutional investors and hedge funds held shares of Spyre Therapeutics Inc.. The most heavily invested institutionals were:
FMR LLC: 11.78 M
BlackRock, Inc.: 5.52 M
RTW INVESTMENTS, LP: 4.17 M
Fairmount Funds Management LLC: 4.02 M
PERCEPTIVE ADVISORS LLC: 3.78 M
VR Adviser, LLC: 3.69 M
23.88% of Spyre Therapeutics Inc. stock is owned by institutional investors.
Institutional investors have bought a total of 84.92 M shares in the last 24 months. This purchase volume represents approximately $3.49 B in transactions.